Comments for MND Research

Comment on MND stem cell study identifies TDP-43 astrocytes as not toxic to motor neurones by stem cell treatments

stem cell treatments — Wed, 15 May 2013 19:38:50 +0000

There are so many cases where the regular mode of treatment seems to be insufficient so at that case research is always open for the right alternate, and in this regard it is the stem cell therapy that is doing amazingly well. Thank you very much.

Comment on Drug for uncontrollable laughing and crying is moving toward European licensing by Owen Palmer

Owen Palmer — Sat, 04 May 2013 11:19:52 +0000

ALISO VIEJO, Calif., April 26, 2013 /PRNewswire/ — Avanir Pharmaceuticals, Inc. (AVNR) today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion for NUEDEXTA® (dextromethorphan hydrobromide and quinidine sulfate), recommending NUEDEXTA be approved for the treatment of pseudobulbar affect (PBA), irrespective of neurologic cause. In addition, the CHMP also recommended approval of two dose strengths of NUEDEXTA; 20/10 mg and 30/10 mg capsules

Comment on New drug for symptom control presented at symposium by Owen Palmer

Owen Palmer — Wed, 01 May 2013 17:51:54 +0000

Hi Ian – You are a lot closer now, hopefully it will be available within the next 9 months or sooner.

I have followed the progress of Nuedexta in the USA for 8 years, rest assured all that could be done was done by Avanir to obtain a positive CHMP recommendation. It should be rubber stamped by the EC within 67 days of the above date.
For your information Nuedexta is currently undergoing clinical trials for further indications.

Very best regards.
Owen

Comment on Studying the risk of developing MND by Owen Palmer

Owen Palmer — Wed, 01 May 2013 17:40:48 +0000

Comment on MND Association fellowships awarded to promising clinicians | 2013 | MND Association by Jolly Good Fellows! | MND Research

Jolly Good Fellows! | MND Research — Thu, 25 Apr 2013 11:02:08 +0000

[...] recipient of a Lady Edith Wolfson Fellowship, but he has recently been awarded a new five-year Senior Clinical Fellowship through the programme – these are highly prestigious awards, with only one in seven applicants [...]

Comment on New fellowship explores how C9ORF72 causes MND by Jolly Good Fellows! | MND Research

Jolly Good Fellows! | MND Research — Thu, 25 Apr 2013 11:02:06 +0000

[...] Although at a much earlier stage in his research, having started only 6 months ago, Dr Cooper-Knock has already identified some specific gene expression effects that may be distinct to the C9orf72 form of the disease. For more details about Dr Cooper-Knock’s work see our earlier blog post about his fellowship. [...]

Comment on Baking with proteins, mRNA and DNA by Jolly Good Fellows! | MND Research

Jolly Good Fellows! | MND Research — Thu, 25 Apr 2013 11:02:02 +0000

[...] He used an entertaining analogy of making dresses form a pattern to describe the process of how DNA is made into RNA copies which can be ‘tailored’ into slightly different protein designs (to find out more about how DNA makes RNA and subsequently proteins see our earlier blog post). [...]

Comment on Structure of C9ORF72 repeat identified by MND Association funded researchers by Jolly Good Fellows! | MND Research

Jolly Good Fellows! | MND Research — Thu, 25 Apr 2013 11:02:00 +0000

[...] that the repeat expansions can lead to the formation of very stable chemical structures called G-quadruplexes that have been implicated in causing nerve damage in other [...]

Comment on Adaptive licensing and MND by john morton

john morton — Mon, 15 Apr 2013 21:26:12 +0000

I think tthis is wonderful news and very much overdue. If something which has demonstrated efficacy in the lab and safety in phase 1 could be made available to patients willing to sign disclaimers that would be a major breakthrough. If it has proved safe then a patient may ultimately be disappointed but at least gets a chance to treat the illness possibly 2 to 3 years sooner than might otherwise be the case which could well, with mnd, prove to be the difference between life and death.

Comment on New fellowship explores how C9ORF72 causes MND by The C9orf72 mystery begins to unravel even more of its secrets | MND Research

Fri, 05 Apr 2013 16:07:26 +0000

[...] Dr Johnathan Cooper-Knock (Sheffield Institute for Translational Neuroscience, UK) is already trying to identify how C9orf72 causes MND by utilising a genetic technique known as gene expression profiling. He is using samples from the Association’s DNA bank which are positive for the C9orf72 genetic mistake. Gene expression profiling is a technique which allows researchers to understand how the activity of genes contributes towards causing MND. (Traditional genetic studies are designed to look at which genes are affected, rather than their activity – ie when and how). Read more about Johnathan’s project here. [...]