Formaldehyde exposure and increased risk of developing MND

A new study published yesterday in the Journal of Neurology, Neurosurgery and Psychiatry (JNNP) highlights the link between increased exposure to formaldehyde and an increased risk of developing MND.

The study in the USA was conducted by Andrea Roberts and colleagues at the Department of Social and Behavioural Sciences at Harvard. They investigated whether a person’s exposure to formaldehyde in their occupation increased their risk of developing motor neurone disease (MND).20141020_MND Kings College_290

Formaldehyde is a colourless chemical that is used as a preservative in mortuaries, medical laboratories and by undertakers. Exposure occurs primarily by inhaling formaldehyde gas or vapour from the air or by absorbing liquids containing formaldehyde through the skin.

The study found that those with a ‘high intensity’ and probability of exposure to formaldehyde had nearly four times higher risk of developing MND compared to people who had no exposure to formaldehyde. All participants that fitted these criteria were funeral directors. The increased risk of developing MND in this occupation group was only found in men, with no link found for women.

What do these results mean?
‘High intensity’ refers to the frequency and level of exposure to formaldehyde as part of the study participant’s occupation and industry type. The probability of exposure reflected how likely they were to come into contact with this chemical as part of their occupation.

The difference in results for men and women are because fewer women work as funeral directors, and so are less likely to come into contact with formaldehyde. This made the sample size too small to detect possible increased risk of MND in this study.

This is the first time formaldehyde has been identified as a possible cause of MND and further studies are needed to confirm the results from this study. Two other studies have found no link between estimated occupational formaldehyde exposure and MND. However, these studies looked at occupations where the intensity of exposure was generally lower than in this study.

MND is an extremely rare disease, and people have up to a 1 in 300 chance of developing MND in their lifetime. In comparison, people have up to a 1 in 2 chance of developing cancer (1). The results from this study showing four-times increased risk equates to approximately a 1 in 75 chance of funeral directors developing MND.

Lifestyle and environmental factors and MND
It is not known exactly how environmental and lifestyle factors could increase or decrease the risk of developing MND. Occupational risk factors have been studied, including the possible links between military service and developing MND/ALS, and a person’s exposure to heavy metals, pesticides and chemicals.

MND is a complex disease which is still not fully understood, but any research that can contribute to the growing knowledge of causes and contributing factors can only help our progress in understanding MND. A study last year into the causes of MND found that up to six different genetic, lifestyle and environmental factors are needed in order to trigger the disease. Therefore many more studies need to be conducted in order to establish the causes of MND.

The researchers of this study into exposure to formaldehyde have stressed that caution should be applied when interpreting these results, not least because jobs involving high levels of formaldehyde exposure are uncommon and MND is a rare disease.

Useful Links
Online article in the Independent (published 14/07/2015)
Research information sheet A: Overview of MND
More information on the causes of MND
More information on Formaldehyde

Research paper: Roberts AL, Johnson NJ, Cudkowicz ME et al. J Neurol Neurosurg Pyschiatry. 2015  Published online 14/07/2015 doi: 10.1136/jnnp-2015-310750

1. Cancer Research UK (2015), Trends in the lifetime risk of developing cancer in Great Britain: Comparison of risk for those born in 1930 to 1960, Cancer Research UK.

2 thoughts on “Formaldehyde exposure and increased risk of developing MND

  1. A male having worked in Silk industry for many years n was diagnosed with MND after his retirement from work at the age of about 65 yrs. It is not sure if he had to handle/inhale Formaldehyde . Could some other chemical used in Silk industry have similar effect.

    Prof Mohan K Muju
    muju@iitk.ac.in

    currently in VA -USA
    Cell-USA 571-585-7413
    LL 703-713-3822

    • Dear Prof Muju,

      Thank you for your comment.

      Several studies in the USA have looked at whether exposure to certain chemicals or solvents used in some occupations increased the risk of developing ALS, including in the garment making industry. These studies are often contradictory in their findings.

      A study in 2009 found that there was a slight increased risk of developing ALS in those whose employment was categorised as involving dyes or printing inks, but only in those who had been in exposed to chemicals in these industries for over 2000 days.

      A 2013 study on female garment workers in the USA, who had exposure to formaldehyde, found no increased risk of developing ALS compared to the general US population.

      Not being aware of the use of formaldehyde in the silk industry, or which other chemicals are used, I cannot say whether another chemical could have a similar effect in possibly triggering ALS. It would also likely be dependent upon the level and frequency of exposure to the chemical or solvent in question.

      ALS is a complex disease, and exposure to one or several of many different lifestyle and environment risk factors can trigger the disease. Therefore it is difficult to say for certain what triggered ALS in the male you are referring to.

      If you have any other questions please email research@mndassociation.org

      Regards,

      Sara Bolton
      Research Information Co-ordinator
      MND Association, UK

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