ANXA11 – another gene closer to understanding ALS

A new research paper has been published today in the Science Translational Medicine journal, describing a new gene implicated in developing MND. What is this gene and why is it important for our fight against MND?

Although they are not the sole cause of MND, genes play a big role in someone’s probability of developing the disease. A number of such genes that make a person susceptible to developing MND have already been identified, with most of them causing the rarer, inherited form of the disease.

A new addition to a list of genes that are related to development of ALS, the most common form of MND, has been discovered by researchers from King’s College London. Dr Bradley Smith and colleagues screened genetic data of an unusually high number of people of European origin: 751 with inherited – familial – ALS (fALS) and 180 with non-inherited – sporadic – ALS (sALS). Detailed analysis of this data found that specific mutations in the ANXA11 gene are associated with around 1% of all fALS and 1.7% of all sALS cases. Continue reading

A Time for New Researchers to Blossom – PhD studentship Applications

It is that time of year again when we open our Online Summary Application Form for our next round of PhD studentship applications, for projects starting in October 2014. The deadline for summary applications is Friday 3 May 2013.

Last Time
Our last round saw an all time record number of studentship applications. We received 18 summary applications and went on to fund five of these attracting new researchers and institutes.

Promising Young Researcher
Our PhD studentship grants allow us to attract and fund promising young scientists starting their careers in MND research and to help us continue to develop the UK basic research capacity. As with all our research projects, we aim to fund the best of the best. Our rigorous application process allows us to ensure we only fund studentships of the highest quality and of direct relevance to MND. To find out more on our application process please see our grant application process.

We are currently funding 15 studentships; five of these are due to start in October 2013.

We hope this year’s PhD studentship round is as exciting as last year!

More Information
For further information on our studentship grants, please see our research we fund and for more details on how to apply for a PhD studentship. Please see our how to apply for funding.

Attracting Promising Research – Calling for Project Grant Applications

Autumn is fast approaching which means it’s time to open our online summary application form for our next round of research grant applications.

This round is for project grant applications. The deadline for summary applications is Friday 2 November 2012.

Reaching out for researchers

We currently fund ground breaking projects in a number of would class research institutes in Edinburgh, London, Oxford, Sheffield, Cardiff and New York, among others. This flexible approach allows us to fund the best and most promising research regardless of geographical location.

Good researchers are fundamental to good research and developing the MND research workforce, nationally and internationally, is a key element of our Research Strategy.

Getting the best of the best

As with all of the research projects funded by the MND Association, our rigorous application process allows us to ensure we only fund projects of the highest quality and of direct relevance to MND.

The way that we fund research starts with a summary application, which is a concise outline of the proposed project. After the deadline date has passed a decision is made as to whether the summary is relevant to MND and that the project will help us to move toward the aims set out in our Research Strategy. If the summary doesn’t fit, it’s rejected. If all criteria are met, the summary is reviewed by our Biomedical Research Advisory Panel (BRAP).

The reviewer’s comments and scores are then assessed using a two thirds majority rule. Each reviewer scores the summary application. A score under 50 is classed as unsuitable for funding, if it’s over 50 then the applicant is invited to submit a full application.

We hope this year holds yet another exciting round of project grant applications!

More information:

Apply now for an MND Association research project grant.

Find out  how we fund research.

Find out what research we fund.

May The Fourth Be With You – PhD Studentship Applications

Spring has finally sprung and so it’s now time to open our online summary application form for our next round of research grant applications.

This round is for PhD studentship applications, for projects starting in October 2013. The deadline for summary applications is Friday 4 May 2012.

Attracting promising researchers
Through our successful PhD studentship programme we have a track record of attracting and funding promising young scientists to develop their careers in MND research. Since 1998 we have funded 30 studentships, 12 of these are currently ongoing.

We need to continue to develop the UK basic research capacity by attracting more young scientists to develop careers in MND research. We can do this by funding PhD studentships.

Funding the best of the best
As with all of the research projects funded by the MND Association, our rigorous application process allows us to ensure we only fund studentships of the highest quality and of direct relevance to MND.

The way that we fund research starts with a summary application, which is a concise outline of the proposed project. After the deadline date has passed a decision is made as to whether the summary is relevant to ‘classical’ MND and the project aims fit with our Research Strategy. If the summary does not fit, it’s rejected. If all criteria are met, the summary is reviewed by our Biomedical Research Advisory Panel (BRAP).

The reviewer’s comments and scores are then assessed using a two thirds majority rule. Each reviewer scores the summary application. A score under 50 is classed as unsuitable for funding, if it’s over 50 then the applicant is invited to submit a full application.

We hope this year holds an exciting round of PhD studentship applications!

More information:

For further information please see the Prize PhD Studentship Flyer or visit our website www.mndassociation.org

Happy New Year – Quiz answers and round up of 2011!

And the answers to our Christmas Quiz are:

  1. How many neurones does a human have? Billions
  2. Which animal has the largest brain? Bottlenose dolphin
  3. How much does a human brain weigh in comparison with our total average body weight (in percent)? 2
  4. How many DNA samples does the MND Association’s DNA bank hold? 3,400
  5. How many research projects do we currently fund? 44
  6. How much does our research project portfolio currently come to? £7.6m
  7. How many PhD studentships do we currently fund? 12
  8. How many times a year do we have research grant funding rounds? 2
  9. How many unproven MND treatments have ALSUntangled investigated so far? 13
  10. How many stem cell research projects do we fund? 2

At the beginning of a new year, it’s always encouraging to look back on how far we’ve come. The list of MND research achievements continues to grow exponentially every year, and I’m pleased to say that last year was no exception, demonstrating that we really are living in exciting times.

2011 had some important discoveries in the world of MND research to find the answers to what causes MND. A number of MND causing gene mistakes were discovered including C9ORF72, Ubiquilin2 and SQSTM1. With these findings, we now know the cause of approximately 70% of cases of inherited MND – a massive leap from approximately 25-30% of known genetic mistakes the previous year.

Within the team, we’ve also made some promising headway toward our aims set out in our research strategy, by funding and promoting cutting edge research both within the UK and around the world. For example, our groundbreaking biomarker project led by Dr Martin Turner at Oxford yielded its second set of promising results, just three years into the five-year project. Dr Martin Turner also gave an enthralling talk at last year’s International Symposium on ALS/MND on neuroimaging (brain scanning) and he’s regarded as ‘the man’ to speak to in terms of MND neuroimaging on an international level.

As well as the research projects that we fund yielding positive results, and following progress on an international level, we’re also a major player in promoting research. The key to defeating MND lies in fostering strong collaboration between leading researchers around the world  and sharing new understanding of the disease as rapidly as possible. In 2011, we made two huge steps in this:

In January 2011, in conjunction with two leading members of the International Consortium of Stem Cell Networks (the Canadian Stem Cell Network and the UK Stem Cell Network), The New York Stem Cell Foundation and the ALS Association of the USA, we organised an MND stem cell conference. Our workshop brought together 60 of the world’s leading stem cell research experts to shape the development of future international MND stem cell research and to form new research collaborations. We were privileged to organise this event and the research community now have a solid foundation of understanding of where we are in terms of MND stem cell research. Dr Brian Dickie, our Director of Research now also has the honour of being a co-author on the scientific paper from the conference – published in the journal ALS.

In July 2011, we made a further step forward in sharing new understanding rapidly by joining a group of research-funding organisations to fund UK PubMed Central, an online research database containing over two million research articles. This is the first step in the Association’s aim to establish a comprehensive resource for the global MND research community.

We also had a fantastic year for improving the way we fund research and maintaining our high standards.

For our first grants round of the year, a record-breaking 19 full applications were considered for funding by our Biomedical Research Advisory Panel. Only one in five research applications is considered of a high enough standard for funding, but through our rigorous process we can provide our donors with the assurance that they are supporting the ‘very best of the best’ MND research.

Before our second grants round, we announced the successful launch of our online summary application form for researchers applying for grants and PhD studentships. By evolving our summary application process to use an online system, we are able to ensure that our high standards are maintained and that we are using our time efficiently and effectively to fund high-quality research.

We also proudly received our certificate for best practice for our rigorous procedures for funding research from the Association of Medical Research Charities (AMRC) in the UK with a comment saying that we are “considered as setting the standard within the audit”.

You can find out more information on the research projects we currently fund on our research we fund information sheet.

One of our highlights from last year, and the result of over a year’s work in preparation from the research team and our conference team, was the International Symposium on ALS/MND held in Sydney, Australia. We are proud to organise this vital worldwide event every year, and are pleased that last year was successful. Holding the event in different countries around the world enables us to draw new people into the international research community, bringing new ideas and expertise to the field and creating new alliances in the fight against MND.

We took you behind the scenes of last year’s symposium by writing daily blog articles on a multitude of topics. If you’ve not already read these, you can find an introduction to these with links on our blog. Please remember to complete our survey on what you thought of our reporting, as it really helps us to determine whether we should continue to report from the symposium, and whether we should change anything.

We’ve definitely set the bar in 2011 and have a lot to live up to in 2012. We’re really looking forward to see what 2012 holds for MND research, and we hope that you’ll continue to follow our progress on our blog throughout the year.

We wish you a very Happy New Year from all of us in the Research Development Team at the MND Association.